a tool for identifying drug-targetable redox-active disulphides

Duodenase-1

Intramolecular

Cysteine 141 and cysteine 207

A redox-regulated disulphide may form within Duodenase-1 between cysteines 141 and 207 (136 and 201 respectively in this structure).

Details

Redox score ?

84

PDB code

Structure name

bovine duodenase(new serine protease), crystal structure

Structure deposition date

2000-04-14

Thiol separation (Å)

2

Half-sphere exposure sum ?

65

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

141

Residue number B

207

Peptide name

Duodenase-1

Ligandability

Cysteine 141 of Duodenase-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 207 of Duodenase-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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